Bone‐on‐a‐Chip: A Microscale 3D Biomimetic Model to Study Bone Regeneration

Organ‐on‐chip models, developed using microengineering and microfluidic technologies, aim to recreate physiological‐like microenvironments of organs or tissues as a tool study (patho)physiological processes in vitro. On‐chip models bone are relevant for the physiology, diseases regenerative processes. While few bone‐on‐a‐chip exist, recapitulating cellular components bone, these do not incorporate chemical structural characteristics tissue. Herein, development platform is reported that comprises 3D model bone. To build platform, first, produced polymer two‐photon polymerization (2PP) from nano‐computed tomography scan trabecular This then coated with layer mineral‐like calcium phosphate. Finally, integrated inside device suitable cell culture. Human mesenchymal stromal cells, cultured up 21 days, show high viability extensive production extracellular matrix, rich collagen. biomimetic can contribute better understanding related formation remodeling, which turn be used regeneration strategies.